Folate levels and Atopy....

When I was looking into my malformed MTHFR gene and its implications I stumbled upon a couple articles. This one was particularly interesting!! J's IgE level was 750 when she was tested.

http://www.jacionline.org/article/S0091-6749%2809%2900387-X/abstract

The results and conclusion of this study are as follows (copied directly):

Results

Serum folate levels were inversely associated with total IgE levels (P < .001). The odds of a high total IgE level, atopy, and wheeze decreased across quintiles of serum folate levels, indicating a dose-response relationship between serum folate levels and these outcomes. Each of these associations remained statistically significant after adjusting for age, sex, race/ethnicity, and poverty index ratio. Adjusted odds ratios associated with the fifth quintile of folate relative to the first quintile were as follows: high IgE level, 0.70 (95% CI, 0.53-0.92); atopy, 0.69 (95% CI, 0.57-0.85); and wheeze, 0.60 (95% CI, 0.44-0.82). Higher folate levels were also associated with a lower risk of doctor-diagnosed asthma, but this finding was not statistically significant (odds ratio for fifth quintile vs first quintile, 0.84 [95% CI, 0.70-1.02]).

Conclusions

Serum folate levels are inversely associated with high total IgE levels, atopy, and wheeze.

I sent these articles to our allergist and alt. health care provider hoping that we get somewhere with this.  Hopefully both girls will be tested for MTHFR, 3/3 of my family members were positive. MTHFR comes with reduced levels of folate due to poor metabolizing. Keep your fingers crossed!!!